After a global war, the seaside kingdom known as the Valley of the Wind remains one of the last strongholds on Earth untouched by a poisonous jungle and the powerful insects that guard it. Led by the courageous Princess Nausicaä, the people of the Valley engage in an epic struggle to restore the bond between humanity and Earth.
Two sisters move to the country with their father in order to be closer to their hospitalized mother, and discover the surrounding trees are inhabited by Totoros, magical spirits of the forest. When the youngest runs away from home, the older sister seeks help from the spirits to find her.
Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.